Description

2-Fluoro-4-[(4-Methylpiperazin-1-Yl)Methyl]Aniline is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining an aniline core with a fluorinated aromatic ring and a methylpiperazine moiety. This compound matters for its critical role as a key building block in the synthesis of novel, targeted therapeutic agents, enabling precise molecular modifications that are essential for modern drug discovery. Pharmaceutical R&D teams and fine chemical manufacturers need it for developing next-generation small molecule drugs, particularly in oncology and central nervous system (CNS) research, where its structure offers valuable opportunities for optimizing drug potency and selectivity.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and receptor antagonist programs.
• Oncology Drug Discovery: Serves as a core scaffold in the research and development of targeted cancer therapies due to its potential for protein-ligand interaction.
• CNS-Active Compound Synthesis: Used in medicinal chemistry for creating potential treatments for neurological disorders, leveraging the methylpiperazine group's common presence in neuroactive molecules.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag precursor for studying enzyme function and protein interactions in biochemical assays.
• Agrochemical Research: Acts as an intermediate in the development of new generation pesticides and herbicides, where the fluorine atom can enhance metabolic stability.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-Fluoro-4-[(4-Methylpiperazin-1-Yl)Methyl]Aniline
CAS No.	1341886-02-9
Molecular Formula	C12H18FN3
Molecular Weight	223.29 g/mol
Synonyms	2-Fluoro-4-[(4-methyl-1-piperazinyl)methyl]aniline; 4-(Aminomethyl)-3-fluoro-N-methylpiperazine; 1-[(2-Fluoro-4-aminophenyl)methyl]-4-methylpiperazine; Benzenamine, 2-fluoro-4-[(4-methyl-1-piperazinyl)methyl]-; 1341886-02-9; 2-Fluoro-4-(4-methylpiperazin-1-ylmethyl)aniline; 4-[(4-Methylpiperazin-1-yl)methyl]-2-fluoroaniline
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-[(4-Methylpiperazin-1-Yl)Methyl]Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.