Description

3-Bromo-6-(tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid tert-Butyl Ester is a sophisticated, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is of significant value in pharmaceutical research and development, serving as a key intermediate for constructing complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space around the triazolopyrazine core.
• Process Chemistry Development: Serves as a key intermediate in scaling up synthetic routes for potential APIs, leveraging its protected functional groups for selective transformations.
• Library Synthesis for High-Throughput Screening: Employed to generate diverse compound libraries based on the triazolopyrazine scaffold for biological evaluation.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in heterocyclic and organosilicon chemistry.

Basic Information

Product Name	3-Bromo-6-(tert-Butyl-Dimethyl-Silanyloxymethyl)-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid tert-Butyl Ester
CAS No.	1341035-98-0
Molecular Formula	C18H31BrN4O3Si
Molecular Weight	459.46 g/mol
Synonyms	3-Bromo-6-((tert-butyldimethylsilyloxy)methyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester; tert-Butyl 3-bromo-6-(((tert-butyldimethylsilyl)oxy)methyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate; 3-Bromo-6-((TBDMS-oxymethyl))-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylic Acid tert-Butyl Ester; TBDMS-protected Triazolopyrazine Bromo Ester; CAS 1341035-98-0
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR spectroscopy (1H, 13C), and mass spectrometry to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal quality standards and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.