Description

5-Bromo-1,2,3,4-tetrahydro-1,8-naphthyridine is a high-value brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core naphthyridine scaffold, functionalized with a bromine atom, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and insecticides with potentially improved efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	5-Bromo-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS No.	1341035-81-1
Molecular Formula	C8H9BrN2
Molecular Weight	213.08 g/mol
Synonyms	5-Bromo-5,6,7,8-tetrahydro-1,8-naphthyridine; 5-Bromo-1,2,3,4-tetrahydro-[1,8]naphthyridine; 1,8-Naphthyridine, 5-bromo-1,2,3,4-tetrahydro-; 5-Bromo-5,6,7,8-tetrahydro-1,8-naphthyridine; 1341035-81-1; 5-Br-THN
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,2,3,4-tetrahydro-1,8-naphthyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All production follows cGMP principles where applicable, and comprehensive analytical testing is performed using techniques including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.