Description

1-(Prop-2-Yn-1-Yl)Piperazine-2-One is a high-purity, advanced pharmaceutical intermediate featuring a piperazinone core functionalized with a propargyl group. This specific molecular architecture makes it a versatile building block for medicinal chemistry research and the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry: Serves as a crucial scaffold for constructing compound libraries via click chemistry, leveraging its alkyne functionality for Huisgen cycloaddition reactions.
• Protease Inhibitor Synthesis: Used in the preparation of potential inhibitors where the piperazinone moiety can mimic peptide bonds or act as a conformational constraint.
• Kinase Inhibitor Development: Employed as a building block in the synthesis of molecules designed to modulate kinase activity, a prominent target class in modern drug discovery.
• Chemical Biology Probes: The alkyne handle allows for bioconjugation and labeling applications, facilitating the study of biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions as required.

Basic Information

Product Name	1-(Prop-2-Yn-1-Yl)Piperazine-2-One
CAS No.	1340102-42-2
Molecular Formula	C7H10N2O
Molecular Weight	138.17 g/mol
Synonyms	1-Propargylpiperazin-2-one; 1-(2-Propynyl)-2-piperazinone; 2-Piperazinone, 1-(2-propynyl)-; 1-(Prop-2-yn-1-yl)piperazin-2-one; N-Propargyl-2-piperazinone; N-(Prop-2-yn-1-yl)piperazin-2-one; 1-(Prop-2-ynyl)piperazine-2-one
EINECS	Contact for details

Quality Control

Our 1-(Prop-2-Yn-1-Yl)Piperazine-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.