Description

tert-Butyl 4-(2-Chloro-5-Fluoropyrimidin-4-Yl)Piperazine-1-Carboxylate is a high-value, multi-functional chemical intermediate designed for advanced synthesis. This compound is critical for pharmaceutical research and development, serving as a key building block in the creation of novel active pharmaceutical ingredients (APIs). It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries to introduce complex piperazine and halogenated pyrimidine motifs into target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of kinase inhibitors and other targeted therapeutics.
• Agrochemical Research: Used in developing advanced fungicides and herbicides with specific mode-of-action.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and tool compounds.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of complex molecules.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Library Synthesis: Used in combinatorial and parallel chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 4-(2-Chloro-5-Fluoropyrimidin-4-Yl)Piperazine-1-Carboxylate
CAS No.	1338495-22-9
Molecular Formula	C13H17ClFN5O2
Molecular Weight	329.76 g/mol
Synonyms	1-Boc-4-(2-Chloro-5-fluoropyrimidin-4-yl)piperazine; tert-Butyl 4-(2-chloro-5-fluoropyrimidin-4-yl)piperazine-1-carboxylate; 4-(2-Chloro-5-fluoropyrimidin-4-yl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 2-Chloro-5-fluoro-4-(1-piperazinyl)pyrimidine 1-Boc derivative; Boc-4-(2-Chloro-5-fluoropyrimidin-4-yl)piperazine; N-Boc-4-(2-chloro-5-fluoropyrimidin-4-yl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Chloro-5-Fluoropyrimidin-4-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.