Description

7,8,9,10-Tetrahydro-6,10-Methano-6H-Pyrazino[2,3-H][3]Benzazepine 1,4-Dioxide is a high-purity, complex heterocyclic compound with the CAS number 1337563-47-9. This specialized chemical serves as a critical advanced intermediate in modern pharmaceutical research and development. It is primarily required by R&D chemists and process development scientists working in the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals. Its unique fused ring structure makes it a valuable building block for exploring new therapeutic pathways.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	7,8,9,10-Tetrahydro-6,10-Methano-6H-Pyrazino[2,3-H][3]Benzazepine 1,4-Dioxide
CAS No.	1337563-47-9
Molecular Formula	C₁₄H₁₄N₂O₂
Molecular Weight	242.27 g/mol
Synonyms	6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-1,4-dioxide; Tetrahydro-methano-pyrazinobenzazepine dioxide; Pyrazinobenzazepine Dioxide Derivative; CAS 1337563-47-9; 1,4-Dioxo-7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine; Advanced Pharmaceutical Intermediate 1337563-47-9; Complex Fused Heterocycle
EINECS	Contact for details

Quality Control

Our 7,8,9,10-Tetrahydro-6,10-Methano-6H-Pyrazino[2,3-H][3]Benzazepine 1,4-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request. We adhere to cGMP principles where applicable to support our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.