Description

4-((3S)-3-Piperidyl)Benzoic Acid is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its defined stereochemistry and functionalized benzoic acid-piperidine structure make it a critical precursor in modern drug discovery and development. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly those targeting the central nervous system and other receptor-mediated pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Ligand Synthesis: Used in medicinal chemistry for constructing complex molecules that act as ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Chemical Biology Research: Serves as a probe or building block in the study of enzyme mechanisms and protein-ligand interactions.
• Process Chemistry Development: Employed in route scouting and optimization for scalable synthesis of candidate drugs.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	4-((3S)-3-Piperidyl)Benzoic Acid
CAS No.	1335828-36-8
Molecular Formula	C12H15NO2
Molecular Weight	205.25 g/mol
Synonyms	4-[(3S)-3-Piperidinyl]benzoic acid; (S)-4-(3-Piperidyl)benzoic Acid; Benzoic acid, 4-[(3S)-3-piperidinyl]-; 4-(3-Piperidyl)benzoic acid (S-isomer); (S)-3-(4-Carboxyphenyl)piperidine; 4-((S)-Piperidin-3-yl)benzoic acid
EINECS	Contact for details

Quality Control

Our 4-((3S)-3-Piperidyl)Benzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data supporting identity, purity, and chiral integrity, compliant with current industry standards for advanced intermediates. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom synthesis to meet specific pharmacopeial or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.