Description

2-Bromo-5-((2-(Trimethylsilyl)Ethoxy)Methyl)-5H-Pyrrolo[2,3-B]Pyrazine-7-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis. This compound is critical for medicinal chemistry research and development, particularly in the construction of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for novel drug discovery programs.
• Process Chemistry Development: Serves as a critical precursor in scaling up synthetic routes for preclinical and clinical trial material.
• Bioconjugation & Probe Synthesis: The carboxylic acid functionality allows for conjugation to create chemical probes for biological target identification and validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	2-Bromo-5-((2-(Trimethylsilyl)Ethoxy)Methyl)-5H-Pyrrolo[2,3-B]Pyrazine-7-Carboxylic Acid
CAS No.	1334674-90-6
Molecular Formula	C14H20BrN3O3Si
Molecular Weight	402.32 g/mol
Synonyms	2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid; 5H-Pyrrolo[2,3-b]pyrazine-7-carboxylic acid, 2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-; 1334674-90-6; 2-Bromo-5-((2-(TMS)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid; 2-Bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-7-carboxy-5H-pyrrolo[2,3-b]pyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-((2-(Trimethylsilyl)Ethoxy)Methyl)-5H-Pyrrolo[2,3-B]Pyrazine-7-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.