Description

3-Amino-6-Methoxy-n-[(2S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropyl]-5-(Trifluoromethyl)-2-Pyridinecarboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and multiple trifluoromethyl groups, which are critical for modulating the biological activity and metabolic stability of target molecules. This compound is essential for research and development in medicinal chemistry, particularly for creating novel active pharmaceutical ingredients (APIs) with enhanced potency and selectivity. It is primarily needed by pharmaceutical R&D laboratories, agrochemical innovators, and fine chemical manufacturers focused on fluorinated compound synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in oncology, neurology, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl groups improve lipophilicity and biological activity.
• Medicinal Chemistry: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: An important precursor for introducing chiral, fluorinated motifs into more complex molecular architectures.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for the life sciences industry.
• Academic Research: Utilized in university and institutional labs studying fluorination chemistry and the development of new synthetic methodologies.

Basic Information

Item	Detail
Product Name	3-Amino-6-Methoxy-n-[(2S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropyl]-5-(Trifluoromethyl)-2-Pyridinecarboxamide
CAS No.	1334546-77-8
Molecular Formula	C13H14F6N3O3
Molecular Weight	374.26 g/mol
Synonyms	(2S)-3-Amino-N-[3,3,3-trifluoro-2-hydroxy-2-methylpropyl]-6-methoxy-5-(trifluoromethyl)pyridine-2-carboxamide; (S)-3-Amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; 3-Amino-6-methoxy-N-[(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]-5-(trifluoromethyl)pyridine-2-carboxamide; 1334546-77-8; Fluorinated Pyridinecarboxamide Derivative; Chiral Trifluoromethyl Intermediate
EINECS	Contact for details

Quality Control

Our 3-Amino-6-Methoxy-n-[(2S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropyl]-5-(Trifluoromethyl)-2-Pyridinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.