Description

cis-n-Boc-3-Methylpiperidine-4-Carboxylic Acid Methyl Ester is a high-purity, protected piperidine derivative, a crucial chiral building block in modern organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, essential for pharmaceutical research and development. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the 3-methylpiperidine scaffold into target molecules.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scalable synthesis of Active Pharmaceutical Ingredients (APIs) under GMP conditions.
• Peptidomimetics & Bioisosteres: The protected carboxylic acid and ester functionalities make it valuable for constructing peptide mimics and bioisosteric replacements in drug design.
• Agrochemical Synthesis: Used as a building block for developing advanced crop protection agents and pesticides with specific stereochemical requirements.
• Academic & R&D Laboratories: Employed in methodological development and the synthesis of complex natural products or novel chemical entities for biological screening.

Basic Information

Product Name	cis-n-Boc-3-Methylpiperidine-4-Carboxylic Acid Methyl Ester
CAS No.	1334499-78-3
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	Methyl (3R,4S)-1-(tert-butoxycarbonyl)-3-methylpiperidine-4-carboxylate; (3R,4S)-1-Boc-3-methylpiperidine-4-carboxylic acid methyl ester; cis-1-Boc-3-methyl-4-piperidinecarboxylic acid methyl ester; (3R,4S)-1-(tert-Butoxycarbonyl)-3-methyl-4-piperidinecarboxylic Acid Methyl Ester; cis-1-N-Boc-3-methylpiperidine-4-carboxylic acid methyl ester; Boc-3-methylpiperidine-4-carboxylate methyl ester (cis); tert-Butyl (3R,4S)-3-methyl-4-(methoxycarbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our cis-n-Boc-3-Methylpiperidine-4-Carboxylic Acid Methyl Ester is manufactured under strict quality control protocols to ensure high chemical and chiral purity, meeting the stringent requirements of pharmaceutical R&D. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.