Description

tert-Butyl 4-(Aminomethyl)-3,3-difluoro-4-methylpiperidine-1-carboxylate is a high-purity, protected piperidine derivative featuring both a Boc-protected amine and a primary aminomethyl group, making it a versatile and valuable building block for advanced organic synthesis. Its core value proposition lies in its role as a key chiral intermediate for the development of novel pharmaceutical compounds, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its difluorinated piperidine scaffold and orthogonal amine protection.
• Process Chemistry & Scale-up: Serves as a standardized intermediate for the kilogram-scale production of candidate drugs during clinical development phases.
• Agrochemical Synthesis: Potential intermediate for creating novel fungicides or herbicides that leverage the physicochemical properties imparted by the difluoro and amine functional groups.
• Ligand & Catalyst Development: The aminomethyl group can be functionalized to create novel chiral ligands for asymmetric catalysis.
• Peptidomimetics & Bioisosteres: The difluorinated piperidine core is used to mimic peptide bonds or other functional groups, improving metabolic stability and bioavailability in drug design.

Basic Information

Product Name	tert-Butyl 4-(Aminomethyl)-3,3-difluoro-4-methylpiperidine-1-carboxylate
CAS No.	1334416-48-6
Molecular Formula	C13H24F2N2O2
Molecular Weight	278.34 g/mol
Synonyms	1-Boc-4-(aminomethyl)-3,3-difluoro-4-methylpiperidine; 4-(Aminomethyl)-3,3-difluoro-4-methylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(aminomethyl)-3,3-difluoro-4-methyl-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(aminomethyl)-3,3-difluoro-4-methylpiperidine; BOC-4-(Aminomethyl)-3,3-difluoro-4-methylpiperidine; 3,3-Difluoro-4-methyl-4-piperidinemethanamine, 1-(1,1-dimethylethyl) ester; 4-(Aminomethyl)-3,3-difluoro-4-methylpiperidine hydrochloride, BOC-protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Aminomethyl)-3,3-difluoro-4-methylpiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and other critical parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (nitrogen or argon) after opening to prevent degradation from moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.