Description

(S)-Methyl Piperazine-2-Carboxylate 2Hcl is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold essential for developing active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• API Development: Serves as a crucial building block for constructing complex molecular architectures in active pharmaceutical ingredient (API) process development and scale-up.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in asymmetric synthesis to introduce stereogenic centers with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Peptidomimetics: Acts as a constrained amino acid analog in the design and synthesis of peptidomimetic compounds.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	(S)-Methyl Piperazine-2-Carboxylate 2Hcl
CAS No.	1334173-77-1
Molecular Formula	C6H14N2O2 • 2HCl
Molecular Weight	227.11 g/mol (for free base: 146.19 g/mol)
Synonyms	(S)-Methyl 2-piperazinecarboxylate dihydrochloride; (2S)-Methyl piperazine-2-carboxylate hydrochloride; Methyl (S)-piperazine-2-carboxylate dihydrochloride; (S)-2-Methoxycarbonylpiperazine dihydrochloride; L-Pipecolic acid methyl ester dihydrochloride (related); (S)-1,4-Diazinane-2-carboxylic acid methyl ester dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Methyl Piperazine-2-Carboxylate 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.