Description

(S)-tert-Butyl 3-Propanamidopiperidine-1-Carboxylate is a high-purity chiral piperidine derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules with defined stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs). This compound is particularly needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including potential candidates for neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetic Chemistry: Used in the synthesis of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability of drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in asymmetric catalytic reactions to introduce stereogenic centers.
• Medicinal Chemistry Research: Serves as a scaffold for constructing focused libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Chemical Biology Probes: A component in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(S)-tert-Butyl 3-Propanamidopiperidine-1-Carboxylate
CAS No.	1332765-81-7
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	1-Boc-3-propionamido-(S)-piperidine; (S)-1-(tert-Butoxycarbonyl)-3-propionamidopiperidine; tert-Butyl (3S)-3-(propionylamino)piperidine-1-carboxylate; (S)-3-Propionamido-1-Boc-piperidine; 1-N-Boc-3-propionamido-(S)-piperidine; (S)-N-Boc-3-propionamidopiperidine; (S)-1-Boc-3-(propionylamino)piperidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 3-Propanamidopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97%), and impurity profile is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.