Description

Benzyl-Peg8-Ms is a specialized bifunctional polyethylene glycol (PEG) derivative, featuring a benzyl-protected hydroxyl group at one terminus and a reactive mesylate (Ms) group at the other. This molecular architecture is critical for creating stable, hydrophilic linkers in advanced bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and polymer chemistry to introduce PEG spacers or to functionalize molecules under controlled conditions.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing hydrophilic, cleavable, or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Used to introduce polyethylene glycol chains onto peptides, proteins, or small molecules to enhance solubility, stability, and circulation time.
• Polymer Chemistry & Material Science: Acts as a functional monomer or cross-linking agent for synthesizing hydrogels, smart materials, and biocompatible coatings.
• Proteomics & Bioconjugation: Facilitates the site-specific labeling of biomolecules for diagnostic assays, imaging probes, and affinity purification systems.
• Pharmaceutical Intermediates: Employed in the synthesis of complex active pharmaceutical ingredients (APIs) requiring PEG-based solubilizing units.
• Diagnostic Reagent Manufacturing: Used in the production of reagents for immunoassays and biosensors that require controlled surface functionalization.

Basic Information

Product Name	Benzyl-Peg8-Ms
CAS No.	1330059-91-0
Molecular Formula	C24H42O11S
Molecular Weight	538.66 g/mol
Synonyms	Benzyl-PEG8-mesylate; Benzyl-octaethylene glycol monomesylate; 1-(Benzyloxy)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl methanesulfonate; PEG8-Benzyl-Ms; α-Benzyl-ω-mesyl-octaethylene glycol; Benzyl-PEG8-OMs; Benzyl-PEG8-sulfonate ester; Benzyl-PEG8-methylsulfonate
EINECS	Contact for details

Quality Control

Our Benzyl-Peg8-Ms is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements. We adhere to cGMP guidelines for the production of materials intended for research and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.