Description

2-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, functionalized pyridine derivative containing a pinacol boronate ester group, making it a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for the development of novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, especially those containing cyclopropyl and heteroaromatic motifs prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyridine-based structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 2-cyclopropylpyridin-4-yl moiety into target molecules.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & Process R&D: A valuable reagent for methodology development and scaling up synthetic routes in both academic and industrial research settings.

Basic Information

Product Name	2-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1321518-37-9
Molecular Formula	C14H20BNO2
Molecular Weight	245.13 g/mol
Synonyms	2-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropylpyridine; 2-Cyclopropylpyridine-4-boronic acid pinacol ester; 2-Cyclopropyl-4-pyridinylboronic acid pinacol ester; 4-Borono-2-cyclopropylpyridine pinacol ester; 2-Cyclopropyl-4-(pinacolboranyl)pyridine; 2-Cyclopropyl-4-pyridylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.