Description

3-Iodo-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and agrochemicals. Researchers and process chemists in medicinal chemistry and fine chemical manufacturing need this specific iodinated pyrrolopyridine derivative to introduce key structural motifs and enable further functionalization via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Agrochemical Development: Serves as a building block for creating novel active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Can be incorporated into organic electronic materials and ligands for catalytic systems.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for Suzuki, Stille, and other palladium-catalyzed coupling reactions to form new carbon-carbon bonds.
• Chemical Biology: Useful for synthesizing molecular probes and labeled compounds for biological studies.

Basic Information

Product Name	3-Iodo-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1316228-21-3
Molecular Formula	C12H13IN2O2
Molecular Weight	344.15 g/mol
Synonyms	1-Boc-3-iodo-7-azaindole; tert-Butyl 3-iodo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate; 3-Iodo-1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester; 3-Iodo-7-azaindole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-iodo-1H-pyrrolo[3,2-b]pyridine; 3-Iodo-1-Boc-7-azaindole; 3-Iodo-1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Iodo-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.