Description

tert-Butyl 4-[(4-Bromo-2-Methylbenzene)Sulfonyl]Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a Boc (tert-butoxycarbonyl) group and functionalized with a brominated arylsulfonyl moiety. This compound is critically important for its role as a versatile building block in medicinal chemistry, enabling the synthesis of complex molecules with potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel drug candidates, especially those targeting protein-protein interactions and enzyme inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable sulfonyl and bromo functional groups.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Can be utilized to create tool compounds and probes for investigating biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	tert-Butyl 4-[(4-Bromo-2-Methylbenzene)Sulfonyl]Piperazine-1-Carboxylate
CAS No.	1315571-51-7
Molecular Formula	C16H23BrN2O4S
Molecular Weight	419.33 g/mol
Synonyms	1-Boc-4-((4-bromo-2-methylphenyl)sulfonyl)piperazine; tert-Butyl 4-(4-bromo-2-methylbenzenesulfonyl)piperazine-1-carboxylate; 4-Bromo-2-methylbenzenesulfonic acid 1-Boc-piperazin-4-yl ester; 1-(tert-Butoxycarbonyl)-4-[(4-bromo-2-methylphenyl)sulfonyl]piperazine; BOC-Piperazine-4-(4-bromo-2-methylbenzenesulfonyl); 1315571-51-7; 4-(4-Bromo-2-methylphenylsulfonyl)-1-piperazinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(4-Bromo-2-Methylbenzene)Sulfonyl]Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.