Description

5-Bromo-2-tert-Butyloxycarbonylamino-6-Methylpyridine-3-Boronic Acid Pinacol Ester is a high-value, multi-functional chemical building block designed for advanced synthesis. Its core value lies in combining a protected amine, a halogen handle, and a boronic ester functional group, enabling precise and sequential cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients. The CAS number for this compound is 1315351-28-0.

Application

This versatile boronic ester is a key intermediate in modern synthetic chemistry, particularly in the construction of complex heterocyclic systems. Its primary applications include:

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The boronic ester functionality enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides to form biaryl linkages, a cornerstone of medicinal chemistry.
• Protected Amine Synthon: The tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection and further functionalization of the amine site under mild acidic conditions.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides requiring complex pyridine-based scaffolds.
• Material Science: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other advanced materials.
• Chemical Biology & Probe Development: Useful for creating tagged molecules or probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-Bromo-2-tert-Butyloxycarbonylamino-6-Methylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1315351-28-0
Molecular Formula	C17H26BBrN2O4
Molecular Weight	397.12 g/mol
Synonyms	5-Bromo-2-((tert-butoxycarbonyl)amino)-6-methylpyridine-3-boronic acid pinacol ester; 2-((tert-Butoxycarbonyl)amino)-5-bromo-6-methylpyridine-3-boronic acid pinacol ester; 3-Boronic acid, 5-bromo-2-[[(1,1-dimethylethoxy)carbonyl]amino]-6-methyl-, pinacol ester; 5-Bromo-2-(Boc-amino)-6-methylpyridin-3-ylboronic acid pinacol ester; Boc-Protected 5-Bromo-6-methyl-3-pyridineboronic acid pinacol ester; (5-Bromo-2-(N-Boc-amino)-6-methyl-3-pyridyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive cross-coupling reactions. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.