Description

tert-Butyl 4-(4-Amino-2-Bromophenyl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine and brominated aniline core structure. This compound is of significant value for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), leveraging its reactive amino and bromo functional groups for further derivatization.
• Bioconjugation & Probe Development: The aromatic amine group can be utilized for conjugation reactions in the development of biochemical probes and labeled compounds for diagnostic applications.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects, from milligram-scale research to kilogram-scale pilot production for clinical trial material manufacturing.

Basic Information

Product Name	tert-Butyl 4-(4-Amino-2-Bromophenyl)Piperazine-1-Carboxylate
CAS No.	1314985-71-1
Molecular Formula	C15H22BrN3O2
Molecular Weight	356.26 g/mol
Synonyms	1-Boc-4-(4-Amino-2-bromophenyl)piperazine; tert-Butyl 4-(4-amino-2-bromophenyl)-1-piperazinecarboxylate; 4-(4-Amino-2-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester; 2-Bromo-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)aniline; 1-Piperazinecarboxylic acid, 4-(4-amino-2-bromophenyl)-, 1,1-dimethylethyl ester; 1314985-71-1; Boc-4-(4-Amino-2-bromophenyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Amino-2-Bromophenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and cGMP intermediate production. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.