Description

(3R,4R)-1-Boc-4-Fluoro-3-Piperidinol CAS NO 1314641-02-5 is a high-purity, chiral piperidine derivative featuring a Boc-protected amine and a fluorinated alcohol moiety. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate in modern organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, especially those targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and functional group versatility.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Protease Inhibitor Development: A potential scaffold for the design of inhibitors targeting specific enzymes.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study biological pathways and protein interactions.
• Process Chemistry & Scale-up: Serves as a starting material for the development of robust, scalable synthetic routes to candidate drugs.

Basic Information

Product Name	(3R,4R)-1-Boc-4-Fluoro-3-Piperidinol
CAS No.	1314641-02-5
Molecular Formula	C10H18FNO3
Molecular Weight	219.26 g/mol
Synonyms	1-Boc-4-fluoro-3-piperidinol, (3R,4R)-; tert-Butyl (3R,4R)-4-fluoro-3-hydroxypiperidine-1-carboxylate; (3R,4R)-4-Fluoro-1-[(2-methyl-2-propanyl)oxycarbonyl]-3-piperidinol; (3R,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-3-piperidinol; (3R,4R)-N-Boc-4-fluoro-3-hydroxypiperidine; (3R,4R)-4-Fluoro-3-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; BOC-(3R,4R)-4-fluoro-3-piperidinol
EINECS	Contact for details

Quality Control

Our (3R,4R)-1-Boc-4-Fluoro-3-Piperidinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.