Description

1-tert-Butyl 4-Methyl 4-(Chloromethyl)Piperidine-1,4-Dicarboxylate is a high-value, protected piperidine derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its molecular architecture, featuring a reactive chloromethyl group and orthogonal carboxylate protecting groups, makes it an essential building block for constructing complex nitrogen-containing molecules. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents and receptor modulators.
• Agrochemical Synthesis: Building block for creating novel pesticides, herbicides, and fungicides with piperidine scaffolds.
• Chemical Biology & Proteomics: Used in the development of molecular probes, affinity tags, and linker molecules for bioconjugation.
• Material Science Research: Monomer or precursor for specialty polymers and functional materials requiring specific nitrogen heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic & Industrial R&D: Employed in medicinal chemistry laboratories for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	1-tert-Butyl 4-Methyl 4-(Chloromethyl)Piperidine-1,4-Dicarboxylate
CAS No.	1314319-01-1
Molecular Formula	C13H22ClNO4
Molecular Weight	291.77 g/mol
Synonyms	4-(Chloromethyl)-1-(tert-butoxycarbonyl)-4-(methoxycarbonyl)piperidine; 1-Boc-4-(Chloromethyl)-4-(Methoxycarbonyl)piperidine; tert-Butyl 4-(chloromethyl)-4-(methoxycarbonyl)piperidine-1-carboxylate; 4-(Chloromethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-(methoxycarbonyl)piperidine; 1-N-Boc-4-(Chloromethyl)-4-piperidinecarboxylic Acid Methyl Ester; Boc-4-(Chloromethyl)-4-piperidinecarboxylic Acid Methyl Ester; 4-(Chloromethyl)-4-(methoxycarbonyl)piperidine-1-carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 4-Methyl 4-(Chloromethyl)Piperidine-1,4-Dicarboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ISO 9001, and REACH requirements for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.