Description

tert-Butyl (3R,4S)-3-Amino-4-Hydroxypiperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical industry, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates targeting central nervous system (CNS) disorders, infectious diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in medicinal chemistry programs.
• API Development: Used in the research and scale-up production of Active Pharmaceutical Ingredients (APIs) requiring a stereochemically pure piperidine core.
• Protease Inhibitor Synthesis: Serves as a crucial precursor in the development of protease inhibitors for antiviral and anticancer therapies.
• Neurological Drug Candidates: Employed as a building block for compounds targeting neurological receptors and enzymes.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands for asymmetric synthesis.
• Chemical Biology & Probe Development: Used to create molecular probes for studying biological pathways and enzyme functions.
• Process Chemistry & Route Scouting: Provides a versatile intermediate for optimizing synthetic routes during process development.
• Academic & Contract Research: Supplied to academic institutions and CROs (Contract Research Organizations) for exploratory research and custom synthesis projects.

Basic Information

Product Name	tert-Butyl (3R,4S)-3-Amino-4-Hydroxypiperidine-1-Carboxylate
CAS No.	1312798-50-7
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	1-Boc-3-amino-4-hydroxypiperidine (3R,4S)-isomer; (3R,4S)-1-(tert-Butoxycarbonyl)-3-amino-4-hydroxypiperidine; tert-Butyl (3R,4S)-3-amino-4-hydroxypiperidine-1-carboxylate; (3R,4S)-3-Amino-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; Boc-3-amino-4-hydroxy-piperidine (3R,4S); (3R,4S)-3-Amino-4-piperidinol, 1-Boc-protected; 1-N-Boc-3-amino-4-hydroxypiperidine (3R,4S)
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R,4S)-3-Amino-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.