Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 2-[[(Cyanomethyl)[(4-Methylphenyl)Sulfonyl]Amino]Methyl]-5-Fluoro-1-(Phenylsulfonyl)-, Methyl Ester is a sophisticated, high-purity pharmaceutical intermediate designed for advanced synthetic applications. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing kinase inhibitors and other targeted therapies. The precise functionalization of its pyrrolopyridine core makes it a valuable building block for creating compounds with specific biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound Synthesis: Employed to create probes for studying cellular signaling pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clients.
• Academic Research: Used in university and institutional labs for exploratory research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 2-[[(Cyanomethyl)[(4-Methylphenyl)Sulfonyl]Amino]Methyl]-5-Fluoro-1-(Phenylsulfonyl)-, Methyl Ester
CAS No.	1312755-50-2
Molecular Formula	C25H21FN4O6S2
Molecular Weight	556.59 g/mol
Synonyms	Methyl 2-(((cyanomethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-fluoro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 2-[[(cyanomethyl)[(4-methylphenyl)sulfonyl]amino]methyl]-5-fluoro-1-(phenylsulfonyl)-, methyl ester; 5-Fluoro-2-((N-(cyanomethyl)-4-methylphenylsulfonamido)methyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; CAS 1312755-50-2
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 2-[[(Cyanomethyl)[(4-Methylphenyl)Sulfonyl]Amino]Methyl]-5-Fluoro-1-(Phenylsulfonyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.