Description

tert-Butyl 4-(Chloromethyl)-4-Formylpiperidine-1-Carboxylate is a versatile and high-value piperidine derivative, serving as a critical bifunctional building block in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a formyl (aldehyde) group on the same carbon, makes it indispensable for constructing complex nitrogen-containing heterocycles and pharmacophores. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to construct novel pesticide and herbicide molecules, leveraging its piperidine scaffold for biological activity.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker molecule for constructing bifunctional degraders due to its two orthogonal reactive sites.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and advanced organic frameworks.
• Academic & Contract Research: Essential for methodological development and exploring new synthetic routes in organic chemistry laboratories.

Basic Information

Product Name	tert-Butyl 4-(Chloromethyl)-4-Formylpiperidine-1-Carboxylate
CAS No.	1312131-48-8
Molecular Formula	C12H20ClNO3
Molecular Weight	261.75 g/mol
Synonyms	1-Boc-4-(chloromethyl)-4-formylpiperidine; 4-(Chloromethyl)-4-formyl-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 4-(chloromethyl)-4-oxo-1-piperidinecarboxylate (tautomer); 1-(tert-Butoxycarbonyl)-4-(chloromethyl)-4-formylpiperidine; 4-Formyl-4-(chloromethyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(chloromethyl)-4-formylpiperidine; Boc-4-(chloromethyl)-4-formylpiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Chloromethyl)-4-Formylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation and hydrolysis. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.