Description

6-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery, active ingredient synthesis, and functional polymer development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated heterocyclic compounds with potential therapeutic activity.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the pyridine and fluorine motifs are common for bioactivity.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as ligands for catalysts, organic semiconductors, or liquid crystals.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl or vinyl halides, facilitating the rapid assembly of biaryl and other conjugated systems.
• Chemical Library Development: Employed in combinatorial chemistry and parallel synthesis for generating diverse compound libraries for high-throughput screening in drug discovery.
• Fluorine Chemistry: The presence of the fluorine atom allows for the study of structure-activity relationships (SAR) and the modulation of compound properties like metabolic stability and lipophilicity.

Basic Information

Product Name	6-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1310405-22-1
Molecular Formula	C13H19BFNO2
Molecular Weight	251.11 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-2-methylpyridine; 2-Methyl-6-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Fluoro-2-methylpyridine-3-boronic acid pinacol ester; (6-Fluoro-2-methylpyridin-3-yl)boronic acid pinacol ester; 3-Borono-6-fluoro-2-methylpyridine pinacol ester; CAS 1310405-22-1; 1310405-22-1
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.