Description

6-Bromo-2-Fluoropyridine-3-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a key reagent in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for palladium-catalyzed coupling with aryl/heteroaryl halides to form biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require fluorinated and brominated pyridine motifs for enhanced activity.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science: A precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors, where the pyridine core provides electron-accepting properties.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	6-Bromo-2-Fluoropyridine-3-Boronic Acid Pinacol Ester
CAS No.	1310404-04-6
Molecular Formula	C11H14BBrFNO2
Molecular Weight	300.95 g/mol
Synonyms	(6-Bromo-2-fluoropyridin-3-yl)boronic acid pinacol ester; 2-Fluoro-6-bromopyridine-3-boronic acid pinacol ester; 3-Bromo-6-fluoro-2-pyridineboronic acid pinacol ester; Pinacol (6-Bromo-2-fluoro-3-pyridinyl)boronate; 6-Bromo-2-fluoro-3-pyridineboronic acid pinacol ester; 6-Bromo-2-fluoropyridine-3-boronic acid, pinacol ester; 1310404-04-6
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Fluoropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.