Description

2-Fluoro-6-Methylpyridine-4-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated pyridine cores in drug discovery programs, particularly for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluoromethylpyridine moiety enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating functionalized ligands in catalysis and for synthesizing organic electronic materials.
• Cross-Coupling Reactions: The pinacol ester group offers enhanced stability and handling compared to the free boronic acid, making it ideal for Suzuki-Miyaura couplings under diverse conditions.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Fluoro-6-Methylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	1310384-07-6
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(6-methyl-2-fluoropyridin-4-yl)-1,3,2-dioxaborolane; 2-Fluoro-6-methylpyridine-4-boronic acid pinacol ester; (6-Methyl-2-fluoropyridin-4-yl)boronic acid pinacol ester; 2-Fluoro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-6-methylpyridine; 1310384-07-6; Pinacol (2-fluoro-6-methylpyridin-4-yl)boronate
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Methylpyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.