Description

2-Chloro-5-Methylpyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in drug discovery for oncology and CNS disorders.
• Agrochemical Synthesis: Used to create advanced pyridine-based herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for developing organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for studying biological pathways and protein interactions.
• Catalyst & Ligand Development: Acts as a building block for creating novel ligands used in asymmetric catalysis and transition metal complexes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	2-Chloro-5-Methylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1309982-62-4
Molecular Formula	C12H17BClNO2
Molecular Weight	253.53 g/mol
Synonyms	(2-Chloro-5-methylpyridin-3-yl)boronic acid pinacol ester; 2-Chloro-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Boronic acid, 2-chloro-5-methylpyridine-, pinacol ester; 2-Chloro-5-methylpyridine-3-boronic acid neopentyl glycol ester (common alternative); Pinacol (2-chloro-5-methyl-3-pyridinyl)boronate; Boronic acid, B-(2-chloro-5-methyl-3-pyridinyl)-, 1,1,1',1'-tetramethyl-2,2'-bi-1,3,2-benzodioxaborole; CAS 1309982-62-4
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency essential for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.