Description

2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a highly functionalized pyridine derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the strategic combination of a reactive pinacol boronate ester group and a halogenated, amine-substituted aromatic core, enabling versatile cross-coupling and further functionalization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for constructing complex drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the pyridine scaffold is a common pharmacophore.
• Material Science Research: Serves as a monomer or functional unit in the synthesis of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Probe Development: Utilized to create tagged molecules or activity-based probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.
• Academic Research: Employed in university and institutional labs for methodological development in organoboron chemistry and heterocyclic synthesis.

Basic Information

Product Name	2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1309980-57-1
Molecular Formula	C15H21BFIN2O2
Molecular Weight	430.06 g/mol
Synonyms	2-Fluoro-4-iodo-6-(pyrrolidin-1-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Boronic acid, 2-fluoro-4-iodo-6-(1-pyrrolidinyl)pyridine-, pinacol ester; 2-Fluoro-4-iodo-6-pyrrolidin-1-yl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine; 1309980-57-1; 2-Fluoro-4-iodo-6-(pyrrolidin-1-yl)pyridine-3-boronic acid pinacol ester; 6-(Pyrrolidin-1-yl)-2-fluoro-4-iodopyridine-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.