Description

7-Bromo-2-Chloro-1,5-Naphthyridine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its halogenated naphthyridine structure, which provides versatile reactivity for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides due to its bioactive scaffold.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for target validation and mechanistic studies.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and drug discovery campaigns.

Basic Information

Product Name	7-Bromo-2-Chloro-1,5-Naphthyridine
CAS No.	1309774-03-5
Molecular Formula	C8H4BrClN2
Molecular Weight	243.49 g/mol
Synonyms	2-Chloro-7-bromo-1,5-naphthyridine; 1,5-Naphthyridine, 7-bromo-2-chloro-; 7-Bromo-2-chloro-[1,5]naphthyridine; 1309774-03-5; AKOS026710893; Z57127455; 2-Chloro-7-bromo-[1,5]naphthyridine
EINECS	Contact for details

Quality Control

Our 7-Bromo-2-Chloro-1,5-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a comprehensive Certificate of Analysis (COA) with every shipment, detailing all critical quality attributes. Our standard grade typically meets a purity specification of ≥95% (HPLC), with higher purities available upon request to support your specific research or cGMP development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, we recommend keeping the material at 2-8°C under an inert atmosphere to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.