Description

2-Chloro-5,6-Difluoronicotinonitrile is a high-value, multi-functional chemical intermediate featuring a halogenated and fluorinated pyridine core. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and active pharmaceutical ingredients (APIs), where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in organometallic chemistry to create specialized ligands for catalytic processes.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for client-specific projects.
• Academic and Industrial R&D: Utilized in exploratory chemistry for discovering new chemical entities and reaction pathways.

Basic Information

Product Name	2-Chloro-5,6-Difluoronicotinonitrile
CAS No.	1309371-71-8
Molecular Formula	C6HClF2N2
Molecular Weight	174.54 g/mol
Synonyms	2-Chloro-5,6-difluoropyridine-3-carbonitrile; 3-Cyano-2-chloro-5,6-difluoropyridine; 5,6-Difluoro-2-chloronicotinonitrile; 2-Chloro-5,6-difluoro-3-pyridinecarbonitrile; Nicotinonitrile, 2-chloro-5,6-difluoro-; 1309371-71-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-5,6-Difluoronicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.