Description

7,7-Difluorooctahydropyrrolo[1,2-A]Pyrazine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated pyrrolopyrazine core, a privileged scaffold in medicinal chemistry. This compound is critical for research and development programs focused on novel therapeutics, particularly in central nervous system (CNS) and oncology targets, due to its ability to modulate pharmacokinetic properties like metabolic stability and membrane permeability. It is an essential building block for synthetic chemists and process development teams in pharmaceutical, biotechnology, and fine chemical industries seeking to accelerate drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and oncology drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine atoms, enhancing potency and metabolic stability.
• Process Chemistry & Scale-up: Serves as a critical starting material for the pilot-scale and commercial-scale synthesis of complex drug molecules.
• Bioconjugation & Probe Development: The dihydrochloride salt form and reactive nitrogen sites make it suitable for creating chemical probes and bioconjugates for biological testing.
• Library Synthesis for High-Throughput Screening: Employed in the construction of focused compound libraries for screening against novel biological targets.

Basic Information

Product Name	7,7-Difluorooctahydropyrrolo[1,2-A]Pyrazine Dihydrochloride
CAS No.	1305712-21-3
Molecular Formula	C7H12Cl2F2N2
Molecular Weight	233.09 g/mol
Synonyms	7,7-Difluorohexahydro-1H-pyrrolo[1,2-a]pyrazine dihydrochloride; 1H-Pyrrolo[1,2-a]pyrazine, hexahydro-7,7-difluoro-, dihydrochloride; 7,7-Difluorooctahydropyrrolo[1,2-a]pyrazine hydrochloride (1:2); Difluoropyrrolopyrazine dihydrochloride; 7,7-Difluoro-1,2,3,3a,4,5,6,7a-octahydropyrrolo[1,2-a]pyrazine dihydrochloride
EINECS	Contact for details

Quality Control

Our 7,7-Difluorooctahydropyrrolo[1,2-A]Pyrazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.