Description

5-Iodo-1H-Pyrazolo[3,4-B]Pyridine is a high-purity, heterocyclic organic compound featuring a fused pyrazolopyridine core with an iodine substituent, serving as a critical building block in advanced chemical synthesis. This compound matters because it provides a versatile and reactive halogenated scaffold essential for constructing complex molecular architectures, particularly in pharmaceutical discovery. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, cross-coupling reactions, and the development of novel functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings to introduce the pyrazolopyridine moiety.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the development of organic electronic materials, ligands for catalysis, and advanced polymers.
• Chemical Biology: Acts as a probe or tag in bioconjugation and labeling studies due to its reactive iodine handle.

Basic Information

Product Name	5-Iodo-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1305324-99-5
Molecular Formula	C6H4IN3
Molecular Weight	245.02 g/mol
Synonyms	5-Iodo-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 5-iodo-; 5-Iodo-1H-pyrazolo[3,4-b]pyridine; 5-Iodopyrazolo[3,4-b]pyridine; 1305324-99-5; 5-Iodo-1H-pyrazolo[3,4-b]pyridin; 5-Iodo-1H-pyrazolo[3,4-b]pyridine (9CI)
EINECS	Contact for details

Quality Control

Our 5-Iodo-1H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.