Description

2-Pivalamido-5-(Trifluoromethyl)Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl and pivalamido functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily sought after by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl group can impart improved biological activity and environmental persistence.
• Material Science: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: A vital starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client pipelines.

Basic Information

Product Name	2-Pivalamido-5-(Trifluoromethyl)Nicotinic Acid
CAS No.	1305324-88-2
Molecular Formula	C12H11F3N2O3
Molecular Weight	288.22 g/mol
Synonyms	2-(2,2-Dimethylpropanamido)-5-(trifluoromethyl)pyridine-3-carboxylic acid; 5-(Trifluoromethyl)-2-pivalamidonicotinic acid; 2-Pivalamido-5-trifluoromethylnicotinic Acid; Nicotinic acid, 2-pivalamido-5-(trifluoromethyl)-; Pivampicillin related compound; 1305324-88-2
EINECS	Contact for details

Quality Control

Every batch of 2-Pivalamido-5-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent lot-to-lot quality suitable for demanding R&D and scale-up processes. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.