Description

5-Chloro-6-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical research and material science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor research and other targeted therapies.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, leveraging its halogenated pyrrolopyridine core.
• Material Science Research: Acts as a building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	5-Chloro-6-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1305324-81-5
Molecular Formula	C17H26ClIN2Si
Molecular Weight	448.84 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-chloro-6-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Chloro-6-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 5-Chloro-6-Iodopyrrolopyridine; 5-Cl-6-I-1-TIPS-pyrrolo[2,3-b]pyridine; 1-(Triisopropylsilyl)-5-chloro-6-iodo-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere such as nitrogen or argon to maximize long-term stability. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.