Description

7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-8-carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its fused dioxino-pyridine heterocyclic structure. This compound is of significant value for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects targeting central nervous system (CNS) and oncological therapeutics. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially those with fused heterocyclic cores.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Development: A key building block in the pilot and commercial-scale production of Active Pharmaceutical Ingredients (APIs) for various disease targets.
• CNS Drug Synthesis: Particularly relevant for the research and development of central nervous system modulators due to its specific chemical scaffold.
• Oncology Research: Employed in the synthesis of novel small-molecule compounds for investigational anti-cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development pipelines.
• Academic Research: Used in university and institutional labs for advanced studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-8-carbaldehyde
CAS No.	1305324-73-5
Molecular Formula	C9H6ClNO3
Molecular Weight	211.60 g/mol
Synonyms	7-Chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridine-8-carboxaldehyde; 8-Formyl-7-chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 7-Chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridine-8-carbaldehyde; 1305324-73-5; 7-Chloro-2,3-dihydro[1,4]dioxino[2,3-b]pyridine-8-carbaldehyde; 7-Chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridine-8-carbaldehyde; 7-Chloro-2,3-dihydro[1,4]dioxino[2,3-b]pyridine-8-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-8-carbaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.