Description

5-(2,2,2-Trifluoroethoxy)Pyridine-3-Carboxylic Acid is a high-value trifluoroethoxy-substituted pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a pyridine carboxylic acid core with a trifluoroethoxy side chain, makes it indispensable for creating novel compounds with tailored properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in developing next-generation herbicides, fungicides, and insecticides, where the trifluoroethoxy group can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a starting material for creating complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Building block for specialty polymers and advanced electronic materials requiring fluorine-containing motifs for specific performance characteristics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	5-(2,2,2-Trifluoroethoxy)Pyridine-3-Carboxylic Acid
CAS No.	1304787-81-2
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	3-Pyridinecarboxylic acid, 5-(2,2,2-trifluoroethoxy)-; 5-(2,2,2-Trifluoroethoxy)nicotinic acid; 5-(Trifluoroethoxy)pyridine-3-carboxylic acid; 1304787-81-2; Nicotinic acid, 5-(2,2,2-trifluoroethoxy)-; 5-(Trifluoroethoxyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our production of 5-(2,2,2-Trifluoroethoxy)Pyridine-3-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.