Description

1-(5-Fluoropyridin-3-Ylsulfonyl)-1,4-Diazepane is a high-purity, advanced pharmaceutical intermediate featuring a unique diazepane core linked to a fluorinated pyridine-sulfonyl moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential for enhanced target specificity and metabolic stability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Protease Inhibitor Synthesis: The sulfonyl-diazepane structure is valuable in constructing potential inhibitors for various enzymatic targets.
• Ligand and Probe Development: Serves as a scaffold for creating chemical probes in biochemical and pharmacological assays.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke chemical synthesis projects.

Basic Information

Product Name	1-(5-Fluoropyridin-3-Ylsulfonyl)-1,4-Diazepane
CAS No.	1304558-20-0
Molecular Formula	C10H14FN3O2S
Molecular Weight	259.30 g/mol
Synonyms	1,4-Diazepane, 1-[(5-fluoro-3-pyridinyl)sulfonyl]-; 1-(5-Fluoropyridine-3-sulfonyl)-1,4-diazepane; 3-[(1,4-Diazepan-1-yl)sulfonyl]-5-fluoropyridine; 5-Fluoro-3-(1,4-diazepane-1-sulfonyl)pyridine; 1304558-20-0; 1,4-Diazepane-1-sulfonyl-5-fluoropyridine; Fluoropyridinyl sulfonyl diazepane
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoropyridin-3-Ylsulfonyl)-1,4-Diazepane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.