Description

(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-4-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern organic synthesis. Its value lies in its defined stereochemistry and pyrrolopyrazinone core, which is a privileged scaffold in medicinal chemistry for developing bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs) with complex heterocyclic structures.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce stereochemical complexity into target molecules.
• Chemical Biology Probes: Acts as a starting material for synthesizing molecular probes to study biological pathways and protein function.

Basic Information

Product Name	(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-4-One Hydrochloride
CAS No.	1303975-09-8
Molecular Formula	C7H13N3O·HCl
Molecular Weight	191.66 g/mol (Free base: 155.20)
Synonyms	(S)-Octahydropyrrolo[1,2-a]pyrazin-4-one hydrochloride; (S)-1,2,3,3a,4,5,6,7-Octahydropyrrolo[1,2-a]pyrazin-4-one hydrochloride; (S)-Hexahydro-1H-pyrrolo[1,2-a]pyrazin-4(6H)-one hydrochloride; (4S)-Octahydropyrrolo[1,2-a]pyrazin-4-one hydrochloride; (S)-Pyrrolo[1,2-a]pyrazin-4-one, hexahydro-, hydrochloride; Chiral pyrrolopyrazinone hydrochloride; S-PPZ HCl
EINECS	Contact for details

Quality Control

Our (S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-4-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.