Description

1-Boc-4-[(2R)-2-Aminopropyl]-Piperazine 2Hcl is a high-purity, chiral piperazine derivative, specifically the dihydrochloride salt of a Boc-protected aminopropyl intermediate. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its defined stereochemistry and protected amine functionality are essential for precise molecular construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutics, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• API Development: Used in research and process chemistry for constructing the core scaffold or side chains of potential new chemical entities (NCEs).
• Medicinal Chemistry Research: Serves as a versatile building block for creating focused libraries of compounds for structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Employed in the design and synthesis of peptide-like molecules where the piperazine ring enhances pharmacokinetic properties.
• Asymmetric Synthesis: Utilized as a source of chiral amine in stereoselective reactions to create enantiomerically pure final products.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	1-Boc-4-[(2R)-2-Aminopropyl]-Piperazine 2Hcl
CAS No.	1303975-03-2
Molecular Formula	C12H27Cl2N3O2
Molecular Weight	316.27 g/mol
Synonyms	1-Boc-4-[(2R)-2-Aminopropyl]piperazine Dihydrochloride; tert-Butyl 4-[(2R)-2-Aminopropyl]piperazine-1-carboxylate Dihydrochloride; (R)-1-Boc-4-(2-Aminopropyl)piperazine 2HCl; (R)-tert-Butyl 4-(2-aminopropyl)piperazine-1-carboxylate dihydrochloride; 1-(tert-Butoxycarbonyl)-4-[(2R)-2-aminopropyl]piperazine Dihydrochloride; BOC-Piperazine-(R)-2-Aminopropyl Dihydrochloride; 1303975-03-2
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[(2R)-2-Aminopropyl]-Piperazine 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.