Description

(R)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-4-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. This compound is essential for the research and development of novel active pharmaceutical ingredients (APIs), particularly in the fields of central nervous system (CNS) and metabolic disorder therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and advanced fine chemical suppliers seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent drug candidates, especially for neurological and psychiatric applications.
• Asymmetric Synthesis: Used as a precursor for constructing complex molecular architectures with defined stereochemistry in medicinal chemistry.
• Chemical Research: Serves as a valuable reference standard and starting material in academic and industrial research exploring new heterocyclic compounds.
• Process Development: Employed in the scale-up and optimization of synthetic routes for target molecules in pre-clinical and clinical development.

Basic Information

Product Name	(R)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-4-One Hydrochloride
CAS No.	1303974-99-3
Molecular Formula	C8H15ClN2O
Molecular Weight	190.67 g/mol
Synonyms	(R)-Octahydro-1H-pyrrolo[1,2-a]pyrazin-1-one hydrochloride; (R)-1,2,3,3a,4,5,6,7-Octahydropyrrolo[1,2-a]pyrazin-1-one hydrochloride; (R)-Hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one hydrochloride; (R)-Pyrrolo[1,2-a]pyrazin-4-one, hexahydro-, hydrochloride, (R)-; (R)-1-Oxo-hexahydro-pyrrolo[1,2-a]pyrazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-4-One Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.