Description

1-tert-Butyl 3-Methyl 4,4-Difluoropiperidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine scaffold. This compound is critical for medicinal chemists seeking to modulate the physicochemical and metabolic properties of drug candidates through strategic fluorine incorporation. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs) across therapeutic areas, including central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting protease and kinase enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the bioisosteric effects of the difluoropiperidine moiety on potency, selectivity, and metabolic stability.
• Preclinical Development: Employed in the scale-up synthesis of lead compounds for toxicological and pharmacokinetic evaluation.
• Chemical Biology Probes: Acts as a precursor for labeled compounds used in target identification and validation studies.
• Agrochemical Research: Potential application in the development of new active ingredients with enhanced properties.

Basic Information

Product Name	1-tert-Butyl 3-Methyl 4,4-Difluoropiperidine-1,3-Dicarboxylate
CAS No.	1303974-67-5
Molecular Formula	C13H21F2NO4
Molecular Weight	293.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-methyl 4,4-difluoropiperidine-1,3-dicarboxylate; 1-Boc-3-methyl 4,4-difluoropiperidine-1,3-dicarboxylate; tert-Butyl 3-methyl 4,4-difluoro-1,3-piperidinedicarboxylate; 4,4-Difluoropiperidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester; Boc-4,4-difluoropiperidine-3-carboxylic acid methyl ester; N-Boc-4,4-difluoropipecolic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 3-Methyl 4,4-Difluoropiperidine-1,3-Dicarboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our facilities operate under a quality system designed to meet the rigorous standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.