Description

3,3-Difluoropiperidine-4-Carboxylic Acid Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated piperidine scaffold. This compound is of significant commercial value for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients. It is primarily sought after by research organizations and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoropiperidine moiety can enhance bioactivity.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of specialized polymers and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3,3-Difluoropiperidine-4-Carboxylic Acid Hcl
CAS No.	1303974-04-0
Molecular Formula	C6H10F2NO2 • HCl
Molecular Weight	209.61 g/mol (Free base: 164.15)
Synonyms	4-Piperidinecarboxylic acid, 3,3-difluoro-, hydrochloride (1:1); 3,3-Difluoropiperidine-4-carboxylic acid hydrochloride; 3,3-Difluoro-4-piperidinecarboxylic acid HCl; 3,3-Difluoronipecotic acid hydrochloride; (3,3-Difluoropiperidin-4-yl)carboxylic acid hydrochloride; 1303974-04-0 (CAS); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 3,3-Difluoropiperidine-4-Carboxylic Acid Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) are provided with each shipment, detailing all critical quality attributes. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.