Description

(E)-n-(5-Fluoro-4-((Hydroxyimino)Methyl)-3-Iodopyridin-2-Yl)Pivalamide CAS NO 1300019-69-5 is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated pyridine structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and CNS drug discovery programs.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies due to its fluoro and iodo substituents, which are valuable for modulating pharmacokinetic properties.
• Preclinical Development: Serves as a critical material for producing compounds required for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthesis projects requiring halogenated heterocycles.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(E)-n-(5-Fluoro-4-((Hydroxyimino)Methyl)-3-Iodopyridin-2-Yl)Pivalamide
CAS No.	1300019-69-5
Molecular Formula	C11H13FIN3O2
Molecular Weight	365.14 g/mol
Synonyms	(E)-N-(5-Fluoro-4-(hydroxyiminomethyl)-3-iodopyridin-2-yl)-2,2-dimethylpropanamide; 2,2-Dimethyl-N-[5-fluoro-4-[(E)-hydroxyiminomethyl]-3-iodo-2-pyridyl]propanamide; Pivalamide, N-[5-fluoro-4-[(E)-(hydroxyimino)methyl]-3-iodo-2-pyridinyl]-; 1300019-69-5; 5-Fluoro-4-((hydroxyimino)methyl)-3-iodopyridine-2-carboxamide, N-tert-butyl-; (E)-5-Fluoro-4-(hydroxyiminomethyl)-3-iodopyridine-2-carboxylic acid tert-butylamide
EINECS	Contact for details

Quality Control

Our (E)-n-(5-Fluoro-4-((Hydroxyimino)Methyl)-3-Iodopyridin-2-Yl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and consistency for your critical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.