Description

tert-Butyl 5-Iodo-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate is a high-value, heterocyclic building block featuring a reactive iodine substituent and a Boc-protected pyrazole nitrogen. This compound is essential for medicinal chemistry research and pharmaceutical development, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily used by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors to create novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The iodine atom serves as an excellent handle for palladium-catalyzed coupling with boronic acids to form biaryl structures.
• Buchwald-Hartwig Amination: Used in C-N bond-forming reactions to introduce amine functionalities into the pyrazolopyridine core.
• Sonogashira Coupling: Enables the introduction of alkynes for further derivatization and molecular diversification.
• Agrochemical Research: Employed in the discovery and development of new active ingredients for crop protection.
• Material Science: Serves as a building block for organic electronic materials and ligands for catalysis.

Basic Information

Product Name	tert-Butyl 5-Iodo-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate
CAS No.	1299607-57-0
Molecular Formula	C11H12IN3O2
Molecular Weight	345.14 g/mol
Synonyms	1-Boc-5-iodo-1H-pyrazolo[3,4-b]pyridine; tert-Butyl 5-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 5-Iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylic acid, 5-iodo-, 1,1-dimethylethyl ester; 5-Iodo-1-Boc-1H-pyrazolo[3,4-b]pyridine; 1299607-57-0
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-Iodo-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and reactivity. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area Percent)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.