Description

I-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol derivative featuring a terminal tert-butyl ester group. This compound is valued for its role as a versatile building block and protecting group in sophisticated organic synthesis, particularly in the development of pharmaceuticals and advanced materials. It is essential for researchers and manufacturers in the fields of bioconjugation, prodrug design, and polymer chemistry who require precise chemical functionality and reliable purity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), prodrugs, and antibody-drug conjugates (ADCs).
• Bioconjugation Linker: Used to attach drugs, dyes, or other molecules to proteins, peptides, or nanoparticles, leveraging its PEG spacer for improved solubility and pharmacokinetics.
• Polymer Chemistry: Serves as a functional monomer or initiator in the synthesis of tailored PEG-based copolymers and hydrogels.
• Protecting Group Strategy: The acid-labile tert-butyl ester group is utilized for the temporary protection of carboxylic acids during multi-step synthetic sequences.
• Material Science: Incorporation into surface coatings and functional materials to modify hydrophilicity and biocompatibility.
• Research & Development: A valuable tool for chemical biologists and medicinal chemists exploring new drug delivery systems and diagnostic agents.

Basic Information

Product Name	I-Peg4-T-Butyl Ester
CAS No.	1291090-31-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; 15-Amino-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester; tert-Butyl 15-amino-4,7,10,13-tetraoxapentadecanoate; Fmoc-PEG4-t-butyl ester; Boc-NH-PEG4-COOtBu; Amino-PEG4-t-butyl ester; Azido-PEG4-t-butyl ester; DBCO-PEG4-t-butyl ester
EINECS	Contact for details

Quality Control

Our I-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere after each use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.