Description

(Meso-1R,5S,8R)-3-(tert-Butoxycarbonyl)-3-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a rigid bicyclic scaffold with orthogonal protecting groups. This compound matters as a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), offering precise stereochemical control. It is primarily needed by research and development teams in the pharmaceutical and biotechnology industries for creating novel therapeutics, particularly in the areas of neurology and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a standardized building block for scaling up API synthesis under current Good Manufacturing Practice (cGMP) conditions.
• Asymmetric Synthesis: Exploits its defined stereochemistry for constructing enantiomerically pure compounds in catalytic reactions.
• Peptidomimetic Design: The constrained bicyclic structure is utilized to mimic peptide turn conformations in drug design.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Item	Details
Product Name	(Meso-1R,5S,8R)-3-(tert-Butoxycarbonyl)-3-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid
CAS No.	1290626-04-8
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	(1R,5S,8R)-8-Carboxy-3-[(2-methylpropan-2-yl)oxycarbonyl]-3-azabicyclo[3.2.1]octane; 3-[(tert-Butoxycarbonyl)]-3-azabicyclo[3.2.1]octane-8-carboxylic acid, (1R,5S,8R)-; Boc-3-Aza-bicyclo[3.2.1]octane-8-carboxylic acid (meso isomer); endo-(1R,5S,8R)-Boc-3-azabicyclo[3.2.1]octane-8-carboxylic acid; (1R,5S,8R)-3-Boc-3-azabicyclo[3.2.1]octane-8-carboxylic acid; Boc-Azabicyclo[3.2.1]octane-carboxylic acid; CAS 1290626-04-8
EINECS	Contact for details

Quality Control

Our (Meso-1R,5S,8R)-3-(tert-Butoxycarbonyl)-3-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at 2-8°C in a dry environment. The compound is moisture-sensitive; allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.