Description

1-(3-Fluoro-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride is a high-purity, fluorinated piperazine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and oncology therapeutics. It is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop new drug candidates with optimized properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and scalable production of novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs, especially for CNS-targeted molecules.
• API Synthesis: Serves as a crucial building block in multi-step synthetic routes for complex, fluorinated active pharmaceutical ingredients.
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and kilogram-scale production for clinical trial material.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for bespoke chemical synthesis services catering to the life sciences sector.

Basic Information

Product Name	1-(3-Fluoro-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride
CAS No.	1289384-73-1
Molecular Formula	C12H16FN3O2 • HCl
Molecular Weight	289.73 g/mol (Free base: 253.28 g/mol)
Synonyms	1-[(3-Fluorophenyl)methyl]-2-piperazinecarboxylic acid hydrochloride; (3-Fluorobenzyl)piperazine-2-carboxylic acid hydrochloride; 1-(3-Fluorobenzyl)piperazine-2-carboxylic acid HCl; 2-Piperazinecarboxylic acid, 1-[(3-fluorophenyl)methyl]-, hydrochloride (1:1); (S)- or (R)-1-(3-Fluorobenzyl)piperazine-2-carboxylic acid hydrochloride (enantiomers); CAS 1289384-73-1
EINECS	Contact for details

Quality Control

Our 1-(3-Fluoro-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profile is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture uptake. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.