Description

1-(4-Fluoro-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride is a high-purity, synthetically versatile piperazine derivative used as a critical building block in pharmaceutical research and development. This compound matters as a key chiral intermediate for constructing complex molecules, particularly in the synthesis of potential drug candidates targeting central nervous system and other therapeutic areas. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need this material for lead optimization, process development, and scale-up activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in lead compound synthesis and structure-activity relationship (SAR) studies, particularly for CNS-targeting drugs.
• Process Chemistry: Serves as a starting material or intermediate in the development and optimization of scalable synthetic routes.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Custom Synthesis: A foundational component for the contract manufacturing of specialized, high-value fine chemicals.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-(4-Fluoro-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride
CAS No.	1289384-65-1
Molecular Formula	C13H17FN2O2 • HCl
Molecular Weight	288.75 g/mol
Synonyms	1-[(4-Fluorophenyl)methyl]piperazine-2-carboxylic acid hydrochloride; (S)-1-(4-Fluorobenzyl)piperazine-2-carboxylic acid hydrochloride; (R)-1-(4-Fluorobenzyl)piperazine-2-carboxylic acid hydrochloride; 1-(4-Fluorobenzyl)piperazine-2-carboxylic acid HCl; 2-Piperazinecarboxylic acid, 1-[(4-fluorophenyl)methyl]-, hydrochloride; 1289384-65-1; 4-Fluoro-benzyl-piperazine-2-carboxylic acid hydrochloride; Fmoc-Pip(4-F-Bzl)-OH (related protected form)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and residual solvents are available upon request. We adhere to cGMP principles for the manufacture of materials intended for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specified)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.