Description

[(5R,6S,9R)-5-Chloro-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-5H-Cyclohepta[B]Pyridin-9-Yl]Oxy-Tri(Propan-2-Yl)Silane is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined molecular architecture. This compound matters as a critical building block in modern synthetic organic chemistry, enabling the development of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of complex small-molecule drugs, particularly within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-inflammatory targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its unique fused ring system and halogen substituents.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the development of efficient, scalable synthetic routes for candidate drugs.
• Organosilane Chemistry: The triisopropylsilyl (TIPS) ether protecting group makes it valuable in multi-step synthetic sequences requiring selective protection and deprotection strategies.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary derivatives for specialized research programs.

Basic Information

Product Name	[(5R,6S,9R)-5-Chloro-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-5H-Cyclohepta[B]Pyridin-9-Yl]Oxy-Tri(Propan-2-Yl)Silane
CAS No.	1289024-04-9
Molecular Formula	C25H32ClF2NO2Si
Molecular Weight	488.07 g/mol
Synonyms	(5R,6S,9R)-5-Chloro-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yloxy-triisopropylsilane; 9-[(Triisopropylsilyl)oxy]-5-chloro-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine; TIPS Ether of (5R,6S,9R)-5-Chloro-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol; Triisopropylsilyl (5R,6S,9R)-5-chloro-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ether; CAS 1289024-04-9
EINECS	Contact for details

Quality Control

Our [(5R,6S,9R)-5-Chloro-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-5H-Cyclohepta[B]Pyridin-9-Yl]Oxy-Tri(Propan-2-Yl)Silane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% de
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.